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El mes que viene en... Journal of Urology
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El mes que viene en... Journal of Urology:
Are WHO recommendations to perform two consecutive semen analyses for reliable diagnosis of male infertility still valid? To evaluate whether a second semen analysis as suggested by the World Health Organization (WHO) Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction improves diagnostic reliability in the evaluation of male infertility.
Quality of Care in the Treatment of Localized Intermediate and High Risk Prostate Cancer at Minority Serving Hospitals To investigate quality of care at minority-serving hospitals (MSH) compared to other institutions for men with localized intermediate and high-risk prostate cancer (PCa).
Clinical, pathologic, and oncologic findings of radical prostatectomy patients with extraprostatic extension diagnosed on pre-operative prostate biopsy Prostatic adenocarcinoma (PCa) with extraprostatic extension (EPE) detected on prostate needle biopsy (PNB) is an uncommon finding. We aimed to describe the clinical and pathologic findings in a large cohort of PCa patients treated with radical prostatectomy (RP) who had EPE identified on PNB.
Clinical results of transarterial embolization to control postoperative vascular complications after partial nephrectomy To evaluate the safety and clinical efficacy of transarterial embolization for vascular complications after partial nephrectomy.
Robot-assisted laparoscopic reoperative repair for failed pyeloplasty in children: an updated series Among children with recurrent obstruction after pyeloplasty, reoperative pyeloplasty is commonly utilized. We previously reported on reoperative robot-assisted laparoscopic repair for failed pyeloplasty in 16 children and concluded that short term and intermediate outcomes were comparable to open reoperative repair. This updated series reports on longer-term outcomes from an extended series.
From PADUA to RENAL score and vice versa: Development and validation of a mathematical converter Tumor complexity remains the primary modality by which urologists determine surgical approach and treatment strategy. R.E.N.A.L. and PADUA scores are the most popularly used nephrometry systems. Notwithstanding the common items contributing to the scores, some differences exist between PADUA and R.E.N.A.L. systems, translating into a different final score when assessing the tumor complexity of a renal mass. This represents an issue during quantitative syntheses of literature data and in the setting of retrospective multicentric analyses.
Effect of Vitamin D Therapy on Sexual Function in Women with Sexual Dysfunction and Vitamin D Deficiency: a Randomized, Double-blind, Placebo-controlled Clinical Trial To investigate the effect of vitamin D therapy on sexual function in women with low vitamin D levels and sexual dysfunction.
Utilization of Active Surveillance as Initial Management for Newly Diagnosed Prostate Cancer: Data from the Pennsylvania Urologic Regional Collaborative We aimed to describe contemporary active surveillance (AS) utilization and variation in a regional prostate cancer collaborative, and to identify demographic and disease-specific factors associated with the use of AS for men with newly diagnosed prostate cancer.
Feasibility of a fully-implanted, nickel-sized and shaped tibial nerve stimulator for the treatment of overactive bladder syndrome with urgency urinary incontinence We conducted a clinical feasibility trial to evaluate the safety and efficacy of a fully-implanted, primary battery-powered, nickel-sized and shaped neuromodulation device called the eCoinTM (Valencia Technologies Corp., Valencia, CA, USA) for tibial nerve stimulation to treat refractory urgency urinary incontinence.
The prognostic value of the proportion/architectural patterns of intraductal carcinoma of the prostate (IDC-P) in patients with de novo metastatic prostate cancer Intraductal carcinoma of the prostate (IDC-P) is an adverse prognosticator of prostate cancer (PCa). However, the roles of the IDC-P proportion and architectural patterns in patient outcomes remain unclear.
Risk Prediction of Prostate Cancer with Single Nucleotide Polymorphisms (SNPs) and Prostate-Specific Antigen (PSA) Combined information on single nucleotide polymorphisms (SNPs) and prostate-specific antigen (PSA) offers opportunities for improving the performance of screening by risk stratification. We aimed to predict the risk of prostate cancer (PrCa) based on PSA together with SNPs information.
Describing the Spectrum of Patient Reported Outcomes after Radical Prostatectomy: Providing Information to Improve Patient Counseling and Shared Decision Making Preoperative counseling incorporating the best-case, worst-case, and most-likely outcome scenarios aid patients’ decision making. This information is not readily available for prostate cancer counseling because most patient reported outcomes are presented as averages, which minimize individual patient experiences. Using the Expanded Prostate Index Composite (EPIC), we present data to characterize the best and worst-case after prostatectomy.
Emerging complications following alternative reservoir placement during inflatable penile prosthesis placement: a 5-year multi-institutional experience. Alternative, or ectopic, reservoir placement (ARP) has recently gained popularity among prosthetic surgeons in order to avoid injury to pelvic structures during inflatable penile prosthesis (IPP) implantation. However, the true incidence of complications associated with these new techniques remain understudied. We carried out a 5-year multi-center retrospective study with the aim to evaluate complications related to alternative reservoir placement.
Long-term discontinuations of botulinum toxin A intradetrusor injections for neurogenic detrusor overactivity: a multicenter study Data on long-term outcomes of intradetrusor injections of botulinum toxin A (BTX-A) for neurogenic detrusor overactivity (NDO) are lacking. The aim of the present manuscript was to assess the outcomes of intradetrusor injections of BTX-A for NDO after more than 10 years of follow-up.
Perioperative Oral Nutrition Supplementation Reduces Prevalence of Sarcopenia following Radical Cystectomy: Results of a Prospective Randomized Controlled Trial We designed a prospective randomized controlled pilot trial to investigate the effects of an enriched oral nutrition supplement (ONS) on body composition and clinical outcomes following radical cystectomy (RC).
Estimating Minimally Important Differences for the Bladder Cancer Index Using Distribution- and Anchor-Based Approaches The Bladder Cancer Index is a validated condition-specific health questionnaire assessing urinary, bowel and sexual function and quality of life among bladder cancer patients. We aimed to establish minimally important difference score thresholds that signal clinical importance.
Concurrent radiotherapy and panitumumab after lymph node dissection and induction chemotherapy for invasive bladder cancer In this prospective study we evaluated safety and efficacy of concurrent radiotherapy and panitumumab following neoadjuvant/induction chemotherapy (ICT) and pelvic lymph node dissection (PLND) as a bladder preserving therapy for invasive bladder cancer (BC).
Robotic-assisted radical cystectomy vs open radical cystectomy: systematic review and meta-analysis To perform an updated systematic review and meta-analysis evaluating patient important outcomes for patients undergoing robot-assisted radical cystectomy (RARC) and open radical cystectomy (ORC).
The Impact of Agent Orange Exposure on Prostate Cancer Outcomes This study explores the effect of Agent Orange (AO) exposure on prostate cancer (PCa) survival in Veterans Affairs (VA) patients receiving androgen deprivation therapy (ADT) for advanced PCa.
Psychiatric Diagnoses and Other Factors Associated with Emergency Department Return within 30 Days of Ureteroscopy Emergency department(ED) visits after ureteroscopy(URS) are costly and inconvenient. To better understand those at risk, we aim to identify patient demographic, medical and surgical factors associated with 30-day ED presentation following URS for urolithiasis with particular attention paid to those with a history of a psychiatric diagnosis(PD).
Intravesical gentamicin treatment for recurrent urinary tract infections caused by multidrug-resistant bacteria Antimicrobial resistance leads to complications in the management of recurrent urinary tract infections (rUTIs). In some rUTI patients with limited treatment options, intravenous therapy with reserve antibiotics is often required. In this study we aimed to assess the effectiveness, safety, and feasibility of prophylactic treatment with intravesical gentamicin in patients with refractory rUTI caused by multidrug-resistant (MDR) microorganisms.
Effect of Lesion Location on Prostate Cancer Detection Rate with Magnetic Resonance Imaging Targeted Biopsy in African Americans The updated Prostate Imaging Reporting and Data System version 2 (PI-RADSTM v2) defines different grading parameters for lesions located in the peripheral zone (PZ) versus the transitional zone (TZ) and has contributed to the implementation of magnetic resonance imaging targeted biopsy (MRI-TB). This study evaluated the efficacy of MRI-TB between African American patients with additional consideration for lesion location on MRI.
Post-Surgical Imaging Patterns in Pediatric Nephrolithiasis: Opportunities for Improvement Imaging following surgical intervention for nephrolithiasis is important to define surgical success as well as to ensure no silent obstruction. We assessed nationwide post-surgical imaging patterns in children undergoing ureteroscopy (URS) and shock wave lithotripsy (SWL).
Hypofractionated Radiation Therapy for Localized Prostate Cancer: An ASTRO, ASCO, and AUA Evidence-Based Guideline The aim of this guideline is to present recommendations regarding moderately hypofractionated (240-340 cGy per fraction) and ultrahypofractionated (500 cGy or more per fraction) radiation therapy for localized prostate cancer.
Making a Case for NOT Prescribing Antimuscarinic Drugs to Treat Overactive Bladder in Older Adults
Clinical Utility of Prostate and Tumor Volume-Related Parameters Following Radical Prostatectomy for Localized Prostate Cancer To evaluate whether prediction of biochemical recurrence (BCR) after radical prostatectomy (RP) is enhanced by any of six parameters: prostate volume, total tumor volume (TV), high grade TV, ratio of high grade TV to TV, ratio of TV to prostate volume and/or ratio of high grade TV to prostate volume.
A 52-Week Study of Dose-Adjusted Subcutaneous Testosterone Enanthate in Oil Self-Administered via Disposable Auto-injector This open-label, single-arm, dose-blinded, 52-week, registration-phase study evaluated the efficacy and safety of subcutaneous testosterone enanthate auto-injector (SCTE-AI) administered weekly to men with hypogonadism.
Comparative Genomic Profiling of Refractory/Metastatic Penile and non-Penile Cutaneous Squamous Cell Carcinoma: Implications for Selection of Systemic Therapy Metastatic penile squamous cell carcinoma (mPSCC) is an aggressive malignancy with limited treatment options. We compared the potential therapy impacting genomic alterations (GA) between mPSCC and non-penile cutaneous metastatic squamous cell carcinoma (mCSCC).
Can We Predict Functional Outcomes after Partial Nephrectomy? Percent parenchymal mass-preserved (PPMP) is the primary determinant of functional outcomes after partial nephrectomy (PN). Accurate methods for predicting PPMP based on preoperative imaging could facilitate patient counseling.
3T Multiparametric MRI: Comparison of Performance With and Without Endorectal Coil for Prostate Cancer Detection, PI-RADSv2 Category and Staging with Whole Mount Histopathology Correlation in 429 Patients To investigate performance of 3TmpMRI with and without endorectal coil (ERC) for detection of prostate cancer (PCa) with whole mount histopathology (WMHP) reference.
Role of Residual Fragments on the Risk of Repeat Surgery After Flexible Ureteroscopy and Laser Lithotripsy: Single Center Study To analyze the impact of residual stone fragments seen on abdominal X-ray (KUB) after ureteroscopy and laser lithotripsy (URS) on the risk of repeat surgical intervention.
Post-Operative Opiate Use in Urologic Patients: a Quality Improvement Study Aimed at Improving Opiate Disposal Practices We aimed to determine trends in post-operative opiate management among urologic patients, to identify associations with opiate keeping, and to foster appropriate opiate disposal after surgery via introduction of an educational handout.
Non-neuropathic Neuropathic Bladder: Is it Really Non-neuropathic? Hinman Syndrome is a rare disease with urodynamic findings and clinical course that resemble neuropathic bladder and no neuropathic etiology. Diffusion Tensor Imaging (DTI) is a special magnetic resonance imaging (MRI) technique that has recently been used for peripheral nerves but shown to be applicable for evaluation of lumbosacral plexus. Our aim was to evaluate the lumbosacral plexus using DTI, which was not previously performed in Hinman Syndrome.
Radical prostatectomy after vascular-targeted photodynamic therapy (VTP) with TOOKAD® : feasibility, early and intermediate results and objectives: vascular-targeted photodynamic therapy with TOOKAD® (VTP) is a new therapeutic option for localized prostate cancer (PCa) management. The objectives are to assess the feasibility of radical prostatectomy (RP) after VTP and describe functional and oncological outcomes.
Active surveillance for localized prostate cancer. Nationwide, observational study The objective of this study was to investigate nationwide survival outcomes in men with localized prostate cancer managed on active surveillance.
Female Representation on Journal Editorial Boards-Is Urology Behind the Times?
6-month Results of Selective Bladder Denervation in Women with Refractory Overactive Bladder To report 6-month efficacy and safety outcomes with selective bladder denervation in women with refractory OAB.
Defining Intermediate-Risk Prostate Cancer Suitable for Active Surveillance Active surveillance (AS) for intermediate-risk prostate cancer (PCa) is controversial. Many AS programs are limited to grade group (GG) 1 (Gleason 6) and PSA<10 ng/ml. However, recent guidelines state that AS can be considered for limited GG2 (Gleason 3+4), despite limited data on outcomes. Our objective was to compare prostatectomy outcomes between subgroups of intermediate-risk versus low-risk PCa.
Characterization of a Standardized Postoperative Radiographic and Functional Voiding Trial after One-Stage Bulbar Ventral Onlay Buccal Mucosal Graft Urethroplasty and the Impact on Stricture Recurrence-Free Survival To characterize a standardized postoperative radiographic and functional voiding trial and determine its impact on outcomes after substitution urethroplasty.
Donor Willingness to Accept for Selling a Kidney for Transplantation: Evidence from Iran1
A Prospective Program to Reduce the Clinical Incidence of Clostridium Difficile Colitis Infection after Cystectomy The development of Clostridium difficile infection after cystectomy is associated with significant morbidity and mortality. We implemented a prospective screening program to identify asymptomatic carriers of Clostridium difficile and assessed its impact on clinical Clostridium difficile infection rates compared to historical matched controls.
Minority recruitment trends in phase III prostate cancer clinical trials (2003-2014): progress and critical areas for improvement U.S. minority groups have been historically underrepresented in phase III prostate cancer clinical trials despite often having higher risk disease. This study analyzes enrollment trends of major U.S. racial/ethnic groups in phase III prostate cancer trials between 2003-2014 compared to Surveillance, Epidemiology, and End Results (SEER) incidence data.
Histologic Validation of 11Carbon-Acetate Positron Emission Tomography/Computer Tomography in Detecting Lymph Node Metastases in Prostate Cancer Conventional imaging cannot definitively detect nodal metastases from prostate cancer (PCa). We histologically validated 11-carbon-Acetate (11C-Acetate) PET/CT for identifying nodal metastases, examining PCa factors that influence detection rates.
Can we predict the outcome of oral dissolution therapy for radiolucent renal calculi? ; A prospective study To prospectively, assess the efficacy and predictors of success of oral dissolution therapy (ODT) by alkalinization for lucent renal calculi.
Outpatient robotic unilateral extravesical ureteral reimplantation in the pediatric population: short-term assessment of safety Robotic extravesical ureteral reimplantation has been established as a viable option for surgical management of vesicoureteral reflux. Typically, this procedure is associated with a hospital stay for routine postoperative care. The aim of the study was to assess the short-term safety of robotic unilateral extravesical ureteral reimplantation as a scheduled outpatient procedure in a pediatric population.
Ureteral Complications of Pediatric Renal Transplantation Ureteral complications following renal transplantation are more common in children than in adults. We identify potential risk factors for ureteral complications in pediatric patients.
Grade Groups Provides Improved Predictions of Pathologic and Early Oncologic Outcomes Compared with Gleason Score Risk Groups The grade grouping (GG) system was introduced in 2013. Data from academic centers suggests GG better distinguishes between prostate cancer risk groups than the Gleason score (GS) risk groups. We compared the performance of both for predicting pathological/recurrence outcomes using data from Michigan Urological Surgery Improvement Collaborative (MUSIC).
Which Patients with Negative Magnetic Resonance Imaging Can Safely Avoid Biopsy for Prostate Cancer? To determine if there is a sub-set of men who can avoid prostate biopsy (PBx), based on multi-parametric MRI (mpMRI) and clinical characteristics.
The Impact of Positron Emission Tomography with 18F-Fluciclovine on the Management of Patients with Biochemical Recurrence of Prostate Cancer: Results from the LOCATE Trial The prospective, multicenter LOCATE trial assessed the impact of positron emission tomography/computed tomography (PET/CT) with 18F-fluciclovine on management plans for patients with biochemical recurrence (BCR) of prostate cancer after curative-intent primary therapy.
Role of Stereotactic body radiation therapy in the management of oligometastatic renal cell carcinoma Kidney cancer has been increasing by 1.7% annually. Renal cell carcinoma (RCC) is the most common kidney cancer, and can metastasize. Our aim is to analyze patients treated with Stereotactic Body Radiation Therapy (SBRT) on metastases from RCC.
Coffee, Caffeine Metabolism Genotype, and Disease Progression in Localized Prostate Cancer Patients Managed with Active Surveillance Active surveillance (AS) is increasingly used as a management strategy for localized prostate cancer. Coffee intake has been associated with lower prostate cancer incidence; and we assessed whether coffee was associated with disease progression in men on AS.
Genomic Prostate Score, PI-RADSv2, and Progression in Men with Prostate Cancer on Active Surveillance OncotypeDx Genomic Prostate Score (GPS) is a 17-gene RNA expression assay intended to help guide treatment decisions for men diagnosed with prostate cancer. The Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2) was developed to standardize the risk stratification of lesions identified on multiparametric prostate MRI. We sought to determine whether these tests are associated with increased risk of biopsy upgrade in men on active surveillance (AS).
Ten-year outcomes of renal tumor radiofrequency ablation We sought to review long-term oncological outcomes of patients with renal tumors treated with radiofrequency ablation (RFA) greater than 10 years ago.
International multi-center validation of an intermediate-risk subclassification of prostate cancer treated with radical treatment without hormone therapy The NCCN guidelines recently endorsed a subclassification of intermediate-risk prostate cancer (IR-PCa) into favourable (FIR) and unfavourable (UIR) subgroups. However, this subclassification was developed in a treatment-heterogeneous cohort, hence the natural history of androgen deprivation treatment (ADT)-naïve FIR- and UIR-PCa remains unknown.
PI-RADSv2 Category on 3 Tesla Multiparametric Prostate MRI Predicts Oncologic Outcomes in Gleason 3+4 Prostate Cancer on Biopsy 3TmpMRI with PI-RADSv2 scoring is a common tool in prostate cancer (PCa) diagnosis and informs the likelihood of a cancerous lesion. We sought to investigate whether PI-RADSv2 also predicts adverse pathologic (AP) features mainly in patients with biopsy Gleason score (GS) 3+4.
The Kinetics of Sperm Return and Late Failure Following Vasovasostomy or Vasoepididymostomy: A Systematic Review Vasovasostomy (VV) and vasoepididymostomy (VE) are technically challenging microsurgical reconstructive procedures necessary for men with obstructive azoospermia at the level of the vas deferens or epididymis. Patency rates following VV or VE have been widely described in the literature. However, few reports have discussed the timing of sperm return to the ejaculate following reconstruction as well as the proportion of men that develop late failure following VV or VE. Therefore, the objective of this article is to review the rates and predictors associated with late failures and the timing of sperm returning to the ejaculate following VV and VE.
Serum Testosterone Levels and Prostate Cancer Risk: A Single Post-Hoc Testosterone Measurement is not Informative
Patterns of Relapse and Implications for Post-Nephrectomy Surveillance for Patients with High-Risk Non-Clear Cell Renal Cell Carcinoma: Subgroup Analysis of the Phase 3 ECOG-ACRIN E2805 Trial The natural history of non-clear cell renal cell carcinomas (non-ccRCC) following surgery with curative intent remains poorly defined, with post-operative surveillance informed by guidelines largely intended for clear cell RCC (ccRCC). We evaluated the patterns of relapse and potential implications for post-nephrectomy surveillance for patients with non-ccRCC enrolled in the largest randomized trial of adjuvant anti-angiogenic therapy for high-risk RCC (E2805).
Impact of Post-hospital Syndrome on Penile Prosthesis Outcomes: A Period of Global Health Risk Post-hospital syndrome is an acquired, transient period of health vulnerability following an inpatient admission. This study aims to assess the impact of a preoperative hospitalization on outcomes following penile prosthesis surgery and to optimize surgical timing following an inpatient admission.
Older Age Predicts Biopsy and Radical Prostatectomy Grade Reclassification to Aggressive Prostate Cancer in Men on Active Surveillance Age at prostate cancer (PCa) diagnosis has been positively associated with PCa-specific mortality, and for men on active surveillance (AS), a higher risk of biopsy grade reclassification (BGR) to Gleason score ≥3+4 (grade group [GG]≥2); however, the association between age and BGR to an aggressive phenotype (Gleason score ≥4+3 [GG≥3]) has not been explored.
Efficacy and Safety of On-Demand Clomipramine for the Treatment of Premature Ejaculation: A Multicenter, Randomized, Double-Blind, Phase III Clinical Trial The aim of the present trial is to assess the efficacy of on-demand clomipramine 15 mg administered before sexual intercourse for the treatment of premature ejaculation (PE).
A Clinician’s Guide to Next Generation Imaging in Patients With Advanced Prostate Cancer (Prostate Cancer Radiographic Assessments for Detection of Advanced Recurrence [RADAR] III) The advanced prostate cancer therapeutic landscape has changed dramatically over the last several years, resulting in improved overall survival for patients with both castration-naive and castration-resistant disease. The evolution and development of novel next generation imaging (NGI) techniques will affect diagnostic and therapeutic decision-making. Clinicians must navigate when and which NGI techniques to use and how to adjust treatment strategies based upon their results, oftentimes in the absence of correlative therapeutic data.
Experimental evaluation of human renal kidney stone spectra for intraoperative stone-tissue-instrument analysis using autofluorescence Precision and safety of laser lithotripsy in the upper urinary tract is solely controlled by the surgeon. Laser systems with integrated real-time analysis of target tissues are not available. An intelligent laser system with automated target differentiation and laser feedback control would provide tremendous improvement in patient safety and surgical precision. This study evaluated technical, medical and physical conditions for real-time analysis using fluorescence for future development of a new laser for lithotripsy.
Prognostic value of concomitant carcinoma in situ in the radical cystectomy specimen: A systematic review and meta-analysis To investigate the prognostic impact of concomitant carcinoma in situ (CIS) in radical cystectomy (RC) specimens.
Higher Neural Correlates in Multiple Sclerosis Patients with Neurogenic Overactive Bladder Following Treatment with Intradetrusor Injection of OnabotulinumtoxinA OnabotulinumtoxinA (OnabotA) is a well-described treatment for Neurogenic Overactive Bladder (NOAB) and while its motor effects on detrusor muscle is extensively studied, its sensory effects are not. The aim of this study was to evaluate the impact of intradetrusor OnabotA injection on brain activity in female multiple sclerosis (MS) patients with NOAB.
Continued Five-Alpha Reductase Inhibitor Use After Prostate Cancer Diagnosis and the Risk of Reclassification and Adverse Pathological Outcomes in the Canary Prostate Active Surveillance Study (PASS) Outcomes of patients who enroll in active surveillance (AS) programs for prostate cancer (PCa) while taking five-alpha reductase inhibitors (5-ARIs) have not been well defined. We sought to determine the association of 5-ARI use with risk of reclassification in the Canary Prostate Active Surveillance Study (PASS).
Ecological Momentary Assessment of Factors Associated with Water Intake Among Adolescents with Kidney Stone Disease Maintaining high water intake reduces kidney stone recurrence, but is difficult to do. Strategies to reduce stone recurrence among adolescents are lacking.
Clinical utility of total length Gleason pattern 4 on biopsy in men with Grade Group 2 prostate cancer The ideal methodology for quantifying secondary Gleason pattern 4 (GP4) in men with Grade group (GrdGrp) 2/Gleason score (GS) 3+4=7 on biopsy remains unknown. We compared various methods of GP4 quantification and evaluated their association with adverse pathology at radical prostatectomy (RP).
Predicting Gleason Group Progression for Men on Prostate Cancer Active Surveillance: The Role of a Negative Confirmatory MRI-US Fusion Biopsy Active surveillance (AS) has gained acceptance as an alternative to definitive therapy for many men with prostate cancer (PCa). Confirmatory biopsies to assess the appropriateness of AS are routinely performed and negative biopsies are regarded as a favorable prognostic indicator. Our study sought to determine the prognostic implications of negative multi-parametric magnetic resonance imaging (mpMRI)-transrectal ultrasound (TRUS) guided fusion biopsy (FB) consisting of extended sextant, systematic biopsy (SB) plus mpMRI-guided targeted biopsy of suspicious MRI lesions.
Single nucleotide polymorphisms of HAAO and IRX 6 genes as risk factors for hypospadias We evaluated the association of hypospadias with 17 susceptibility loci previously identified by a European genome-wide association study (GWAS) in Japanese patients. We also examined the expression of candidate genes in male mouse embryos to discuss the possible underlying mechanisms of this disease.
Evaluation of Cancer-Specific Mortality with Surgery Versus Radiation as Primary Therapy for Localized High-Grade Prostate Cancer in Men Younger than 60 Years Old The optimal primary treatment for localized high-grade prostate cancer in younger men remains controversial. The objective of this project was to compare the impact of initial radical prostatectomy versus radiation therapy on survival outcomes for young men <60 years old with high-grade prostate cancer.
A contemporary analysis of dual inflatable penile prosthesis and artificial urinary sphincters outcomes Inflatable penile prostheses (IPP) and artificial urinary sphincters (AUS) are used to treat men with erectile dysfunction (ED) and stress urinary incontinence (SUI), respectively. After treatment of prostate cancer, men often experience ED and SUI. Dual prosthetic implantation can improve the quality of life of these men. We evaluated the reoperation outcomes in men who underwent dual implantation compared to each individually.
Gubernaculum Testis and Cremasteric Vessels Preservation During Laparoscopic Orchidopexy for Intra-Abdominal Testis: Effect on Testicular Atrophy Rates Gubernaculum-sparing laparoscopic orchidopexy (GSLO) - which involves anatomical delivery of the testis through the internal inguinal ring (IIR) - has been proposed as an alternative to Conventional Laparoscopic Fowler-Stephens Orchidopexy (CLO) maximizing collateral blood supply and potentially reducing atrophy rates. Herein, we test this hypothesis by comparing the 2 techniques.
Toileting behaviors of adult women: What is healthy? The objective of this study was to assess toileting behaviors in community-dwelling adult women.
Discrepancies in Self-Reported and Actual Conflicts of Interest in Pediatric Urology Robotic Surgery In assessing publications that address the benefits of robotic surgery over traditional laparoscopic and open approaches, transparency of conflicts of interest (COI) is essential. We sought to assess discrepancies between self-reported and actual COI, and whether or not COI is associated with favorable endorsement of robotic surgery.
Objective assessment of robotic surgical technical skill: A systemic review Robotic surgeries, especially in urology, have grown exponentially over the past decade. Various skill assessment tools have been developed. We review the present status, current challenges, and future needs of robotic evaluations, with a focus on urologic applications.
Oncologic and functional outcome of partial gland ablation with HIFU for localized prostate cancer We assessed the outcomes of high-intensity focused ultrasound for the primary treatment of localized prostate cancer in a retrospective series. This represents one of the largest published series of intermediate and high-risk patients.
cT1a renal masses < 2 versus > 2 cm managed with Robotic Partial Nephrectomy: a propensity-score matched comparison of perioperative Outcomes To perform a single center evaluation comparing the perioperative, pathological and functional outcomes of robotic partial nephrectomy (RPN) for T1a renal masses < 2 cm vs T1a renal masses > 2 cm.
The Value of Urinary BDNF Levels on Assessment of the Botulinum Toxin Type A Treatment for Neurogenic Detrusor Overactivity in Children with Myelodysplasia Urinary cytokines are proposed to predict the urodynamic findings and outcome of intradetrusor botulinum neurotoxin type A injection (iBoNT-Ai) in children with myelodysplasia. The relationship between urinary brain-derived neurotrophic factor (BDNF) and neurogenic and non-neurogenic detrusor overactivity (NDOA) has been shown, as well. In this prospective study, we aimed to investigate the effect of iBoNT-Ai on urine BDNF levels in children with NDOA due to myelodysplasia.
Epidural Analgesia Decreases Narcotic Requirements in Low Level Spina Bifida Patients Undergoing Urologic Laparotomy for Neurogenic Bladder and Bowel Concern of anatomical anomalies and worsening neurologic symptoms has prevented widespread use of epidural catheters in patients with low level spina bifida (LLSB). We hypothesize that thoracic epidural placement in the T9-T10 interspace is safe and decreases narcotic requirements in LLSB patients following major open lower urinary tract reconstruction (LUTR).
Complex robotic lower urinary tract surgeries in patients with previous open surgery We describe our experience with robot assisted complex lower urinary tract reconstruction (CUTR) in patients with previous open abdominal surgery (PAS).
Editorial Comment Acknowledging the limitations of administrative data sets and the inability to demonstrate causality, this study still highlights several important aspects of acute care for children with nephrolithiasis. First, many children will initially present to nonpediatric hospitals, representing an opportunity and need for engaging adult urology and ED colleagues in the care of these children. In addition, although rates of urological consultation were low, urology consult was associated with decreased rates of ED revisits and use of CT.
Re: Influence of Voluntary Pelvic Floor Muscle Contraction and Pelvic Floor Muscle Training on Urethral Closure Pressures: A Systematic Literature Review M. Zubieta, R. L. Carr, M. J. Drake and K. Bø
Re: How Did Medicare Part D Affect Racial and Ethnic Disparities in Drug Coverage? E. Mahmoudi and H. G. Levy
Re: Prospective, Randomized, Multinational Study of Prostatic Urethral Lift versus Transurethral Resection of the Prostate: 12-Month Results from the BPH6 Study J. Sønksen, N. J. Barber, M. J. Speakman, R. Berges, U. Wetterauer, D. Greene, K. D. Sievert, C. R. Chapple, F. Montorsi, J. M. Patterson, L. Fahrenkrug, M. Schoenthaler and C. Gratzke
Editorial Comment This is an interesting article addressing a not too uncommon scenario in which a patient on required antiplatelet therapy is in need of surgical resection of a suspicious renal mass. While it makes complete sense intuitively that patients on clopidogrel can potentially have more bleeding complications, only 8 patients were on continued clopidogrel therapy. Therefore, some observations have to be viewed with caution. For example, the fact that those patients who remained on clopidogrel had longer operative times could be an incidental finding unless the operative notes dictated state that the increased operative time was due to intraoperative bleeding.
Re: Economic Analysis of Prostate-Specific Antigen Screening and Selective Treatment Strategies J. A. Roth, R. Gulati, J. L. Gore, M. R. Cooperberg and R. Etzioni
Re: Conditional Survival after Radical Cystectomy for Bladder Cancer: Evidence for a Patient Changing Risk Profile over Time G. Ploussard, S. F. Shariat, A. Dragomir, L. A. Kluth, E. Xylinas, A. Masson-Lecomte, M. Rieken, M. Rink, K. Matsumoto, E. Kikuchi, T. Klatte, S. A. Boorjian, Y. Lotan, F. Roghmann, A. S. Fairey, Y. Fradet, P. C. Black, R. Rendon, J. Izawa and W. Kassouf
Re: The Artificial Urinary Sphincter after a Quarter of a Century: A Critical Systematic Review of Its Use in Male Non-Neurogenic Incontinence F. Van der Aa, M. J. Drake, G. R. Kasyan, A. Petrolekas and J. N. Cornu; Young Academic Urologists Functional Urology Group
Re: Complications following Artificial Urinary Sphincter Placement after Radical Prostatectomy and Radiotherapy: A Meta-Analysis A. S. Bates, R. M. Martin and T. R. Terry
Re: Penile Prosthesis Insertion in Patients with Refractory Ischaemic Priapism: Early vs Delayed Implantation E. Zacharakis, G. Garaffa, A. A. Raheem, A. N. Christopher, A. Muneer and D. J. Ralph
Re: Urologic Problems in Spina Bifida Patients Transitioning to Adult Care S. J. Summers, S. Elliott, S. McAdams, S. Oottamasathien, W. O. Brant, A. P. Presson, J. Fleck, J. West and J. B. Myers
Re: Reasons for Prescription Change of α1-Blockers in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia T. N. Kim, J. K. Nam, K. S. Lee, T. H. Kim, S. W. Park, D. G. Shin, H. J. Park, W. Lee, Z. Z. Lee and M. K. Chung
Re: Lower Urinary Tract Symptoms Improve with Testosterone Replacement Therapy in Men with Late-Onset Hypogonadism: 5-Year Prospective, Observational and Longitudinal Registry Study D. J. Yassin, Y. El Douaihy, A. A. Yassin, J. Kashanian, R. Shabsigh and P. G. Hammerer
Re: Urologists’ Use of Intensity-Modulated Radiation Therapy for Prostate Cancer J. M. Mitchell
Re: Comprehensive Geriatric Assessment Can Predict Postoperative Morbidity and Mortality in Elderly Patients Undergoing Elective Surgery K. I. Kim, K. H. Park, K. H. Koo, H. S. Han and C. H. Kim
Re: Renal Transplantation after Ex Vivo Normothermic Perfusion: The First Clinical Study S. A. Hosgood
Re: Quantification of the Early Risk of Death in Elderly Kidney Transplant Recipients J. S. Gill, E. Schaeffner, S. Chadban, J. Dong, C. Rose, O. Johnston and J. Gill
Infection and Inflammation of the Genitourinary Tract Y. Madani and B. Mann
Combined ciprofloxacin and amikacin prophylaxis in the prevention of septicaemia after transrectal ultrasound guided biopsy of the prostate
Purely Transvaginal/Perineal Management of Complications From Commerical Prolapse Kits Using a New Prostheses/Grafts Complication Classification System
Response to Letter to the Editor
Re: Sleep Analysis of Patients with Nocturia and Benign Prostatic Obstruction K. Bal, S. Ayik, Y. Issi, A. Bolukbasi and G. Akhan
Re: Involvement of Estrogen Receptors in Prostatic Diseases H. Kawashima and T. Nakatani
Perioperative outcomes and Oncologic Efficacy from a Pilot Prospective Randomized Clinical Trial of Open Versus Robotic Assisted Radical Cystectomy
In Vivo Evaluation of the Third Generation Biodegradable Stent: A Novel Approach to Avoiding the Forgotten Stent Syndrome
Urodynamis Testing- Is it a Useful Tool in the Management of Children with Cutaneous Stigmata of Occult Spinal Dysraphism?
Response to Letter to the Editor
Ureteronenteric Anastomotic Strictures After Radical Cystectomy - Does Operative Approach Matter?
Reply to Michael A. Gorin, Arthur I. Sagalowsky and Mark S. Soloway's Letter to the Editor re: S. Picozzi, C. Ricci, M. Gaeta et al. Upper urinary tract recurrence following radical cystectomy for bladder cancer: a meta-analysis on 13,185 patients. J Urol 2012; 188: 2046–54.
Reply to Letter to the Editor
Re: Limitations of Preoperative Biopsy in Patients with Metastatic Renal Cell Carcinoma: Comparison to Surgical Pathology in 405 Cases To evaluate the ability of preoperative biopsy to identify high-risk pathological features by comparing pathology from preoperative metastatic site and primary tumour biopsies with nephrectomy pathology in patients with metastatic renal cell carcinoma (mRCC).
Response to "Letter to the Editor"
Diagnostic Potential of Urinary 1-Antitrypsin and Apolipoprotein E in the Detection of Bladder Cancer
Re: Ameliorative Effects of Stinging Nettle (Urtica dioica) on Testosterone-Induced Prostatic Hyperplasia in Rats A. Nahata and V. K. Dixit
Re: Persistence of Urgency and Urge Urinary Incontinence in Women with Mixed Urinary Symptoms After Midurethral Slings: A Multivariate Analysis J. K. Lee, P. L. Dwyer, A. Rosamilia, Y. N. Lim, A. Polyakov and K. Stav
WITHDRAWN: Re: Managing a Pessary Business This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at (http://www.elsevier.com/locate/withdrawalpolicy).
Re: Pessary Care: Follow up and Management of Complications K. O'Dell and S. Atnip
Re: Loss of the Urothelial Differentiation Marker FOXA1 is Associated with High Grade, Late Stage Bladder Cancer and Increased Tumor Proliferation Approximately 50% of patients with muscle-invasive bladder cancer (MIBC) develop metastatic disease, which is almost invariably lethal. However, our understanding of pathways that drive aggressive behavior of MIBC is incomplete. Members of the FOXA subfamily of transcription factors are implicated in normal urogenital development and urologic malignancies. FOXA proteins are implicated in normal urothelial differentiation, but their role in bladder cancer is unknown. We examined FOXA expression in commonly used in vitro models of bladder cancer and in human bladder cancer specimens, and used a novel in vivo tissue recombination system to determine the functional significance of FOXA1 expression in bladder cancer.
Prostatic Fibrosis Is Associated With Lower Urinary Tract Symptoms
Post-Implantation Alterations of Polypropylene in the Human
Post-Implantation Alterations of Polypropylene in the Human
RE: Long-Term Infection Outcomes of 3-Piece Antibiotic Impregnated Penile Prostheses Used in Replacement Implant Surgery [Letter to the Editor JU-12-1703]
Response to letter to Editor from Lawrence Klotz re my Editorial Comment on Focal Therapy for Localised Unifocal and Multifocal Prostate Cancer: A Prospective Development Study
Re: Coated Implants and “No Touch” Surgical Technique Decreases Risk of Infection in Inflatable Penile Prosthesis Implantation to 0.46% J. F. Eid, S. K. Wilson, M. Cleves and E. A. Salem
Undescended Testis Histology Correlation with Adult Hormone Levels and Semen Analysis
Response to Comments: Diagnostic Radiation Exposure Risk in A Contemporary Cohort of Male Patients with Germ Cell Tumor
Comparative Effectiveness for Survival and Renal Function of Partial and Radical Nephrectomy for Localized Renal Tumors: A Systematic Review and Meta-Analysis
Reply By Authors: Snodgraft Technıque In The Treatment Of Prımary Dıstal Hypospadıas Repaır: Pushıng The Envelope
Semen Quality in Men Who Sustained a Spinal Cord Injury During the Prepubertal Period