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Este mes en... Nature Reviews Urology

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Este mes en... Nature Reviews Urology:

  • Prostate cancer: Hand in hand — Rb1 and Trp53 cooperate to suppress resistance
    New data presented in Science indicate that Rb1 and Trp53 cooperate to suppress lineage plasticity, metastasis, and resistance to antiandrogens in prostate cancer. These findings, and the development of mouse models of Rb1 and Rb1 and Trp53 (also known
  • Prevention: PFMT reduces the incidence of pelvic-organ-prolapse symptoms
    Pelvic organ prolapse (POP) — a condition involving the descent of the anterior or posterior vaginal wall, the cervix, or the apex of the vagina — can cause urinary, bowel and/or sexual dysfunction, and requires surgery in the majority of patients. Now, data from a
  • Prostate cancer: An abiraterone ultraresponsive phenotype
    Researchers have identified a molecular signature in castration-resistant prostate cancer (CRPC) patient-derived xenografts (PDX) that is associated with a tumour phenotype ultraresponsive to abiraterone.Abiraterone is a CYP17A1 inhibitor that blocks biosynthesis of androgens, and has been shown to improve survival in CRPC. However, some
  • Prostate cancer: On the down-low — low luminal cell CD38 expression is prognostic
    New data, published in Cell Reports, show that luminal progenitor cells expressing low levels of CD38 (termed CD38-low cells) localize to areas of inflammation in human prostate glands. These cells can initiate prostate cancer development and are prognostic for biochemical recurrence and metastasis; furthermore,
  • Urothelial carcinoma: Targeting PD-1 in advanced disease
    Data from the KEYNOTE-012 phase Ib study demonstrate that pembrolizumab, an antibody targeting programmed cell death protein 1 (PD-1), has antitumour activity and an acceptable safety profile in patients with advanced urothelial carcinoma.Several antibodies targeting PD-1 or its ligands are being studied for the
  • Prostate cancer: Light, camera, action – photodynamic therapy for low-risk disease
    New data on padeliporfin vascular-targeted photodynamic therapy for men with low-risk prostate cancer have been published in the Lancet Oncology. The results of this phase III trial show that this therapy is safe and efficacious for treating localized, low-risk disease.Azzouzi and colleagues recruited
  • Prostate cancer: Genomic drivers of BRCA2-mutant tumours
    Aggressiveness of localized prostate tumours with BRCA2 mutations is driven by specific genomic changes, resulting in a metastatic-like phenotype at diagnosis, according to a study published in Nature Communications.An association between germline BRCA2 mutation and prostate cancer risk is well known:
  • Infection: A new threat on the horizon — Zika virus and male fertility
    Amongst the many causes of male-factor infertility, a diagnosed viral cause is a rather infrequent aetiological factor. However, a recent study has illustrated that Zika virus infections affect not only developing fetuses in pregnant women, but are also a threat to fertility in men. Whether this threat could be managed or mitigated remains uncertain.
  • Urothelial carcinoma: The value of extended lymphadenectomy during radical surgery for UTUC
    The prognostic value of lymph node yield on oncological outcomes after radical nephroureterectomy with lymph node dissection in patients with upper tract urothelial carcinomas is unclear. Careful consideration and dedicated research of why, how and for whom lymph node dissection is appropriate are imperative to ensure improvements in patient survival.
  • Antimicrobial-resistant sexually transmitted infections: gonorrhoea and Mycoplasma genitalium
    The emergence of antimicrobial resistance (AMR) is a major concern worldwide and already compromises treatment effectiveness and control of several bacterial sexually transmitted infections (STIs). Neisseria gonorrhoeae and Mycoplasma genitalium are evolving into so-called superbugs that can become resistant, both in vitro
  • Functional urological disorders: a sensitized defence response in the bladder–gut–brain axis
    Functional urological and gastrointestinal disorders are interrelated and characterized by a chronic course and considerable treatment resistance. Urological disorders associated with a sizeable functional effect include overactive bladder (OAB), interstitial cystitis/bladder pain syndrome (IC/BPS), and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Poor treatment outcomes might
  • A spatiotemporal hypothesis for the regulation, role, and targeting of AMPK in prostate cancer
    The 5′-AMP-activated protein kinase (AMPK) is a master regulator of cellular homeostasis. Despite AMPK's known function in physiology, its role in pathological processes such as prostate cancer is enigmatic. However, emerging evidence is now beginning to decode the paradoxical role of AMPK in cancer and,
  • Diagnostic dilemmas in patients with upper tract urothelial carcinoma
    Upper tract urothelial carcinoma (UTUC) is a rare condition and recommendations based on a high level of evidence for diagnosis, treatment and follow-up monitoring are lacking. Current decision-making is often based on evidence from trials investigating urothelial carcinoma of the lower tract. Radical nephroureterectomy has


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