Neuropeptide Y (NPY) is known to be associated with the adrenergic system. The relationship among the late micturition disorders following acute urinary distension, the adrenergic system and NPY was investigated. A total of 90 rats were included in the study of which 30 were taken as the control group. Acute urinary distension was created in 60 rats. The NPY concentration in their bladders was assessed by radioimmunoassay (RIA) for 3 h after distension and subsequently at days 2, 7 and 21 and at the third and sixth months. The NPY concentrations assessed in the third and sixth months were compared with the control group in the same age group and were not distended. Using the RIA method, an outstanding decline of NPY concentration was observed 2 days after distension, while the concentration started to increase by the seventh day ( P=0.003). This increase continued until day 21 ( P=0.004). However, a significant decline was maintained when compared to the concentration before distension. In the third and sixth months, a significant decline was observed in NPY concentration in comparison to the control group ( P=0.004 and 0.005, respectively). Early and late micturition disorders experienced after acute urinary distension may be the result of adrenergic denervation which may be related to NPY.
Content Type Journal Article
Category Original Paper
Erdal Yilmaz, Department of Urology Faculty of Medicine University of Kirikkale 71100 Kirikkale Turkey
Nihat Arikan, Department of Urology Faculty of Medicine University of Ankara Ankara Turkey
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